Difference Between Business Marketing And Consumer Marketing

Armstrong, Adam, Denize Kotler (2011) defines marketing as a management process that is responsible to identify and satisfy customer need and wants. Business to business (B2B) and business to customer (B2C), are two key areas of marketing that is often used to distinguish organization in a particular market. Business marketing is defined as the process of purchase a good or a service from a supplier for consumptions, incorporation and reselling purposes (Hutt Speh 2011). Customer marketing can be referred as the process of purchasing goods and service based on individual consumption (Dant Brown 2008). Business and consumer marketing have similar characteristic in terms of the common values and theory. However, they are often differentiated by the function and strategy within their perspective market. Due to the difference between business and consumer markets, various researcher state that different marketing strategies should be used (Dant Brown 2008; Kolis Jirinova 2013). This p aper will examine and analyze the major difference between business marketing and consumer marketing using supportive evidence within fast moving consumer good industry. Fast moving consumer goods (FMCG) are considered to be a multi-million dollar industry that is composed by a huge range of goods from well-established brands (About FMCG 2014). FMCG products are usually goods that are purchases in the everyday life of an individual or household. Furthermore, the prices for these productsShow MoreRelatedThe 7 Key Differences Between Business-to-Business and Consumer Marketing1932 Words   |  8 PagesThe 7 Key Differences Between business-to-business and consumer marketing by Robert W. Bly When asked if he could write an effective direct mail package on a complex electronic control system, a well-known direct response copywriter replied, â€Å"No problem. It doesn’t matter what the product is. You are selling to people. And people are pretty much the same.† He’s wrong. Yes, there are similarities. But there are also differences in selling to business and professionalRead More B2B vs. B2C Marketing Differences Essay809 Words   |  4 Pagesvs. B2C Marketing Differences Once a decision is made to develop a business, whom the customer will be is the next decision to be made. Whom will the company target as a customer? Will it be a business? Or will it be a consumer? Business-to-business (B2B) marketing has differences from business-to-consumer (B2C) marketing practices. This paper will outline these differences between the two types of e-commerce business transactions. Traditional marketing in the business-to-business environmentRead MoreMarketing Differences B2B vs B2C1077 Words   |  5 PagesMarketing Differences Paper: B2b vs. B2c In two distinct e-commerce business types, Business-to-business (B2B) and Business-to-Consumer (B2C), there are many differences in the way they operate. Specifically in marketing, differences include how the marketing is driven and the values of the strategies, the size of the target market and length of the sales cycle, and even the buying patterns of the target consumers. Each of these differences will be better defined and explained in the followingRead MoreDifference Between B2B and B2C1254 Words   |  6 PagesMarketing: Differences Between B2B and B2C Linicha Hunter University of Phoenix EBUS 400 E-Business Dr. Hee Lee September 27, 2006 Marketing: Differences Between B2B and B2C Marketing allows organizations to promote their products or services with the intent of maximizing their profit and gaining consumers confidence. In today s society marketing the correct product/service can be difficult but implementing the marketing process and planning accurately can alleviate potentialRead MoreVarious Global Marketing Environments1194 Words   |  5 PagesVarious Marketing Environments All the factors that are external to the organization form the marketing environment for it. These factors also form the marketing environment when we talk about it in a global context. These factors cannot be controlled, even though the marketers can influence these factors to some extent. Social environment can have a great deal of effect on marketing globally. By the social environment we mean the consumption trends of groups and individuals. The main factorsRead MoreMarketing Strategies For Business Marketing894 Words   |  4 Pagesis done between two or more companies and does not include the final customer of products is considered to be a business-to-business model. (What is business-to-business (B2B)?, 2016) These types of businesses have distinct differences from business-to-customer companies that raise multiple marketing hurdles to jump. Some of these differences include longer sales cycles, more complex products or services, few identifiable buyers, less buyer research, and different channels for marketing strategiesRead MoreStudy Guide for Intro to Marketing1384 Words   |  6 PagesExplain the difference between a market orientation and a product orientation. Illustrate with concepts and examples. 1 Basic Focus The basic focus of a company with a production orientation is toward maximizing production output. Under a production orientation, a company is succeeding when it is manufacturing as many products as possible at the cheapest possible price. In contrast, a company with a marketing orientation is squarely focused on the consumer. Market-oriented companies respondRead MoreB2B Marketing Paper1266 Words   |  6 Pagesas the major differences between business marketing and consumer marketing? Which of these differences do you believe are the most important? Support your position with reference to an example of a company chosen from one of the following industries: Although business markets and consumer markets share common values and theories, they differ in the way that they function in their respective markets. Organisations need to ensure they understand what makes up a consumer and business market as wellRead MoreB2B And B2C Marketing Strategies Essay1379 Words   |  6 PagesMarketing is an integral part of any business operation, regardless of platform or environment (brick and mortar versus virtual); type of product sold or service rendered and target market. With the advent of Internet technology, new business models or sites such as business-to-business (B2B) and business-to-consumer (B2C), have emerged which require the employment of different marketing strategies and tools to attract and retain customers. The following sections will provide a comparison of theRead MoreImpact Of Emerging Markets On Marketing : Rethinking Existing Perspectives And Practices1074 Words   |  5 PagesCHAPTER 1 INTRODUCTION Research on emerging markets is not just a â€Å"nice thing to do†; it is increasingly becoming a necessity. (Jagadish N Seth, 2011). In his article titled, â€Å"Impact of Emerging Markets on Marketing: Rethinking Existing Perspectives and Practices† published in Journal of Marketing, 2011 he has specified the importance of academic research for understanding Emerging Markets. Emerging markets are those lower-incomes but rapid-growth countries that are using economic liberalization as

Feste Analysis in the First and Second Act of Twealth Night Free Essays

Fools in Shakespeare’s plays appear often. In Othello, the Tempest, Macbeth and many others, the buffoon is represented as an eclectic person paid to say the truth in a comic manner through songs and jokes. Even though Feste in Twelth Night does not speak frequently in the first and second acts, he says enough for us to see that he is an observant and clever man. We will write a custom essay sample on Feste Analysis in the First and Second Act of Twealth Night or any similar topic only for you Order Now Firstly, well associated with the spirit of the twelfth night, the night where society reverses roles, Feste reflects joy. His name is a great example of the happiness he expresses. Feste sounds a lot like the French word  «fete », which means party. In every scene he plays in the second act, he starts to sing. He says to Orsino that he takes  «pleasure in singing » which truly proves his delight in what he does. In other words, he is a man that likes his job. But the name Feste associates with the twelfth night in a traditional way too. He is allowed to say whatever he wishes because he is a licensed fool, as we found out when Olivia referred to him as  «an allowed fool ». This freedom of speech fits in well with the reversal of roles involved in the 12th night ritual. When Olivia orders  «take away the fool », he answers  «take away the lady ». This disrespectful answer would have ended the employment of any of the other servants of the lady. But, even considering the fixed hierarchical structure of society at the time, Feste can say whatever he thinks as long as he says it in song or in a comic manner. Moreover, Feste’s job contrasts with his abilities. Since he is a fool, we expect him to be illiterate, certainly not very perspicacious, but on the contrary, he turns out to be the most intelligent character of the play. This is shown by his developed sense of repartee hidden through his role of jester. For example, in the last scene of the first Act, Maria criticizes Feste of having no real bravery, as he pretends to have, compared with soldiers. He answers that everyone should do what he is good at ( «And those that are fools, let them use their talent.  »). This response seems wise and philosophical. But Feste as a fool is obviously someone with a great sense of humor. Over five hundred years, many ideas about life and society have changed and evolved, but humor has remained universal. Feste’s talent and ability is to shield himself with his persona as a fool, but to offer insights and insults of a very wise man. He never behaves badly or in a juvenile way: playing around with food, drinks or other accessories. His only accessory is language. Scene 3 of Act 2, Sir Andrew jokes about Feste because of his status but Feste replies:  «How now, my hearts! Did you never see the picture of â€Å"We Three†?  » implying that Sir Andrew, Sir Toby and himself are fools. This short answer is hilarious because Sir Andrew is wordless but the silky tone emphasize the comic feature of the quote. It seems to me that fools like Feste have two roles in Shakespeare’s plays. First, they provide comic relief to what might otherwise be a heavy, if not depressing story. We look forward to their appearance to give us an uplift from the more serious developments in the plot. Without the fool this story would have had a totally different tone, simply a depressing tragedy. Second, they are the characters with which we, the audience, identify. Yes, we too are really insightful and we too see all the foibles and vices of the characters and we too would express our thoughts and observations through witty banter if we lived in these social circles in these times, or so we like to think. How to cite Feste Analysis in the First and Second Act of Twealth Night, Essay examples

Introduction Some Time In The History Of The Universe, No One Is Quite Essay Example For Students

Introduction Some Time In The History Of The Universe, No One Is Quite Essay IntroductionSome time in the history of the universe, no one is quite surewhen, there was born a man. This man would eventually be the first tofound a monotheistic religion. The name of this man is Zoroaster; thename is actually a corruption of Zarathushtra. Zoroasters birth date,along with whether his religion is actually monotheistic, is a subjectof great debate. The opinions concerning his birth, and consequentlyabout the beginning of this great religion, range from as early as 6000years before Plato to as late as 500 B.C.E. In any case he was bornsomewhere in Iran, although whether in the East or West is alsoarguable. In the early writings the people belonging to this religionare called Zarathustris; the system he taught is called Mazdaism. Thepresent day followers are called Parsees. Zoroaster removed themultiplicity of deities from religion and created a faith in whichthere were two, or perhaps, one God. All other higher beings wereregarded as demons, or evil spirits. No one knows for sure thedifferent stages of popularity that Zoroastrianism experienced. We doknow that at the time of Darius I, 558?-486 B.C. E., it was protected byroyalty. Later, however, Zoroastrians were continually chased by themembers of the Islamic religion through Kathiawar in India, and Surat,and finally they settled again in Bombay. The universe is thebattleground. The opponents are Mazda Ahura, later to be known asAhura Mazda, and Anra Mainyu, later call ed Ahriman. Ahura Mazda isthe good force and the bad is Ahriman. The battle will last till AhuraMazda defeats Ahriman in the year 12,000 (we are now presumably around11,500). This is the world and its future in accordance withZoroastrian beliefs. ZoroasterZoroaster had a very non-conforming mind and was forced to fleehis parents house without his parents consent because of the rebukinghe gave to those who sacrificed cattle or drank intoxicating haoma. Hefled to the mountains and gave himself to God. Sometime between theages of thirty and forty an angel appeared to him and brought him tothe throne of the highest God, Ahura Mazda. After this occurred, theprophet tried for twelve years to convert people, but to no available. During this period many visions were revaled to him. A milestone inthe progression of the religion occurred when Zoroaster convertedVishtaspa,the king of Persia. He also converted the kings son,brother, counsellor, and grand vizier. Zoroaster married, along withtwo other women, the counsellors daughter. Zoroaster was killed atthe age of seventy-seven by Ardshataspa, a neighboring prince, whoinvaded Vishtaspas capital. According to the Parsees, Vishtaspa isthe father of Darius, who reigned from 521-485 B.C.E. Another viewholds that Zoroaster lived 258 years before Alexander the Great; hewould have therefore lived between 570 and 500 B.C.E. The Greeks tendto place him six thousand years before Plato. Ahura Mazda, while notnecessarily discovered by Zoroaster, was found on an inscription datingaround 714 B.C.E. In ancient Persia, before Zoraosters reforms,religion was polytheistic. Zoroaster objected to these dieties andreferred to them as demons. Many of the rituals and Gods that heremoved were later reinstated due to the fact that the people werestill emotionally attached to them. We can see this from the fact thaton the epigraphs of Artaxerxes II Mnemon (404-358 B.C. E.) the Mithrasand Anahita, ancient gods, are mentioned. Temples and images of Godwere also introduced into the religion at a later date.Zoroastrian BeliefsThe Zoroastrian religion is based on the fundamental concept of aconstant battle of good against evil. The good is represented by AhuraMazda while the bad is represented by Ahriman. Ahura Mazda created thisworld as a trap for Ahriman. Human beings draw Ahriman into thisworld; he will jump at any chance to cause others to do evil. He willthen be entering Ahura Mazdas world, and when people choose good overevil voluntarily this will weaken Ahriman to the point where he can bedestroyed. It is hard to reconcile the two opposing views on thedieties in the Zoroastrian religion. The claim is made that thereligion is monotheistic; it is also alleged that the opposing forcesin the world, good and evil, are represented by two equal gods. Modernday Parsees resolve the contradiction by explaining that Ahura Mazdahas always and will always stand above all. Anra Mainyu, or Ahriman,was only created due to an evil thought that once entered Ahura Mazdashead. The real opponent of Ahriman is Spenta Mainyu, the good spirit.The world is divided into three sections. The upper world is bathed inlight, the earth is divided into seven sections, and the underworld isa dark place. The forces of good and evil will do battle for thetwelve thousand years of the worlds total existence. In thebeginning, as Ahriman attempts to kill Ahura Mazda, he is stopped andpulled away. Both of the Gods agree to a period of peace that willlast 9,000 years. During the first three thousand years Ahura Mazdacreates angels, good spirits, and Frava shis. These Fravashis are theoriginal heavenly images of men living in the upper world. During thenext three thousand years the Fravashis come down to earth. There theylead a perfect sinless life. Anra Mainyu is angry because of theadvantage he sees the Ahura Mazda has gained over him in preparationfor the final battle. He tries to bring evil to the world, but he isrendered powerless by the sacred Ahunavairya formula that Ahura Mazdautters. The Giver - Main Character EssayFrom the mid-nineteenth century and on the Parsis prosperedgreatly. This brought about an increase in the amount of literature.The literat ure was written in many languages including Gujarat (one ofthe previous places of residence) and English. These consisted mainlyof the religions beliefs and observances. The Zoroastrian religionmakes an abrupt turn at this point and changes from its previous highlyorthodox religion and writing. The society is hurt and confusedbecause of a sudden plunge into modernity. The society searched fornew ways to explain the older writings. The writing is transformedinto one writing influenced by the beliefs of many of the surroundingreligions including Christianity and Hinduism. Some writings simplytalk of a belief but advocate no actual observance requiring anyactions. Into the twentieth century the writings decrease and show agreater influence by the Muslims.Zoroastrian HistoryFrom around 550-330 B.C. E. the Iranian tribes left the steppeswhere they had been previously living and conquered and moved intomodern-day Iran. The eastern Iranians brought the Zoroastrian faith tothe western Iranians, the Meads, and the Persians. It became thereligion of the Achaemenian empire. The Avestan writings, however,remained in the eastern dialect. Alexander slaughtered many of theZoroastrian priests thereby also harming the transmission of thetexts.The Asacids, from north-east Iran, later established the secondIranian empire. The empire was called the Parthian empire. The fewwritten records they had indicated a tolerance of the Zoroastrianreligion. This empire ruled from approximately 144 B.C.E. through 224C.E. The Sasanian period was from 224 to 651 C.E. By this timeZoroastrianism had returned to many of the things that Zoroaster hadtaken out at the beginning of the religion. They had gone back totheir old ways of sacrificing, drinking haoma, and believing in morethan one God. However, even as the orthodoxy of the religion declined,its popularity increased to the greatest point in its history.After the fall of t his empire Persia was converted to Islam. About fourteen thousand remain in Iran today. The others eitherconverted or moved to India, where different religions were moretolerated. The Zoroastrians there are called Parsees, and most livearound Bombay. They number about 150,000. They have greatlyprospered, and probably owe this to their honesty and generosity. EthicsZoroaster based his concept of good and evil on the things thathappened to be good and bad for the people of his time. Animals whichwere used for cattle bearing were considered good and created by AhuraMazda. On the other hand, animals which were harmful to cattle werecreated by Ahriman. Large families were praised, and any attempt tostop sex from having children was forbidden. The main purpose of man isalways to make good decisions and to fight with Ahura Mazda against theforces of Ahriman. Life after DeathCadavers are unclean and therefore should not be allow ed to touchthe holy fire and earth. The Zoroastrians have devised a way ofdealing with this in which they place the dead bodies on dakhmas, thetowers of silence. Certain people who have received this position byinheritance, as it is unholy, bring the bodies into these towers. Onceplaced on the towers of silence the bodies are devoured by vultures ina matter of hours. Water is then poured over the bones and is run intothe sea. Modern ways of dealing with the dead are by placing them intocement containers or by burning with electricity. Spiritually, after a person dies, his body remains in the area inwhich he died for three days. After this his conscience appears to himin the form of a woman. If the person had a bad conscience the womanis ugly; if he had a good conscience the woman is beautiful. The womanthen takes him over a bridge called the Chinvat Peretu, theaccountants bridge. If the person led a good life he walks over thebridge into paradise; if he led a bad l ife he falls to hell. If theperson is not evil nor good he reaches the intermediate kingdom,Hamestakans, which is between paradise and hell. After the end of theworld is reached, the spirits will be returned to their bodies and itis only then that their final fate will be decided.ConclusionIn conclusion I think that the following observation correctlysummarizes the enduring contributions of Zoroastrianism. It is aninspired ideology which is based upon three beli efs: there is a battlebetween good and evil, there will be an end to the world together witha final divine judgment and the purification of earth, and there is aparadise, a perfect society in heaven. These ideas have had farreaching effects upon other religions and people. Zoroastrianism hasbrought a concept of a sense of the religious meaning of history alongwith a stronger monotheism and ethics. It has removed the religiousidentification with nature and states of consciousness. There are those that believe that the Ancient Hebrews only adoptedthe concepts of a resurrection of the dead, an end to the world, and afinal judgment, once they came into contact with the Zoroastrians. Allof these ideas are presently important to the Jews, Christians, andMuslims. We can all see how far reaching and important the Zoroastrianreligion has been on the evolution of the important religions out ofwhich most modern civilizations have evolved.

Sculpins Essays - Cottus, Scorpaeniformes, Sculpin, Cottidae

Sculpins Reproduction and early life history of the Sculpin Have you ever personally thought that fish were an interesting subject? Most people dont. The majority of individuals consider fish ordinary, routine and insignificant. However with a closer look, you may discover that fish can be extraordinary and extremely significant in more ways than one. With proper education and better understanding, people will not only realize the importance of the fish, but also the relevance of issues such as the spawning, life history and life span of fish such as Jordania zonope (sculpins). Prior to the spawning season (December-January), the males move into the spawning zone in fresh water or brackish water and are later joined by the females (Krejsa 1967; McAllister and Lindsey 1960), [On-line]. Krejsa (1967) has reported that spawning migration is limited to the coastal population and does not occur in the inland population. Judging from the location of sculpin larvae taken in this study, both migratory and nonmigratory populations exist. Spawning takes place February through June (Krejsa 1967), [On-line]; mainly in March and April (Moyle 1976), [On-line]; February through May (Millikan 1968), [On-line]; January through September; January through May in Central Valley floor waters; and May through September in the foothill creeks. The average temperature for spawning is 8-13 C (Krejsa 1967). The saltinity is 12 ppt (Millikan 1968); freshwater to intertidal (Moyle 1976); freshwater to oligohaline. Some substrates are large cobbles or flat rocks (Krejsa 1967); under surface of rocks, in beer cans, rusting automobile bodies (Millikan1968), [On-line]; trash (Moyle 1976), [On-line]; under-surfaces or crevices of rocky bottoms and banks, jetties; concrete blocks and other artificial substrates. For both fresh and salt water sculpins mating activity occurs mostly at night or during darkened conditions. Freshwater male sculpins cleans and prepares a nest cavity for the female to lay her eggs; when the female lays her eggs she deposits them in clusters on the underside of the nest that the male has prepared for her. The saltwater female sculpin chases a male until she traps him in a crevice. She keeps him there until she lays her eggs. A mature male then fertilizes the eggs. A mature scalyhead sculpin has a well-developed, penis-like appendage that it uses to fertilize the female internally. Sculpin eggs are often brightly colored-green, blue, yellow, orange, pink, red perhaps to warn off predators. This is a form of protective coloration among many species, which use bright colors to warn predators of danger. The number of eggs that are found in the ovary are 336-5,652 and 700-4,000 per cluster (Krejsa 1967); 584-10,980 eggs in ovary (Bond 1963), [On-line]; 280-7,410 eggs in ovary (Patten 1971), [On-line]; 1,094-5,656 (Millikan 1968), [On-line]. Several females may lay their eggs in one males nest. The female may also lay eggs in more that one males nest. After the eggs are laid the male goes into the nest and fertilizes the eggs immediately . The male fish guards the nest three to four weeks or until the fry leave. He aerates the eggs by fanning them with his large pectoral fins until hatching occurs (Krejsa 1967), [On-line]. The reason the male fans the eggs is to keeps the eggs clean from bacteria and to keep oxygen flowing to eggs. The male also removes debris and dead eggs with his mouth from his nest. The father is so attentive, he may net even feed until the eggs hatch. Eggs adhere strongly to one another, but less to other substrates. Incubation is relatively long: 15-16 days at 12 C (Krejsa 1967), 19-20 days at 10-12 C (Mason and Machidori 1976), [On-line] and 14-15 days at nine to 13 C under laboratory conditions. Millikan (1968) noted that hatching rate of prickly sculpin eggs is higher at a salinity of 12 ppt than in fresh water. A Newly fertilized egg is one point four millimeters in diameter. When the egg is in the stage of morula, it is one point four millimeters in diameter. The egg is one point five millimeters in diameter when it is at the early stage of being an embryo. During the late stages of being an embryo the egg is one point five millimeters in diameter. Most of the sculpins eggs

The eNotes Blog Januarys Study Tip How to Beat the Winter QuarterBlues

Januarys Study Tip How to Beat the Winter QuarterBlues Winter is the cruelest of quarters. One day youre making merry and ringing in the new year, the next youre expected to have read all of your coursework and to bounce back to student life with the youth and agility of, well, a student If you feel the winter quarter sads, try these quick tips to stay motivated for your classes: 1. Jazz up your dorm room Cheap and cheerful are the operative words here. Because of winters short days and long nights, your little space can easily turn gloomy, which in turn will affect your mood and how well you study there. Try injecting some extra light with the help of an inexpensive box of Christmas tree lights. Itll feel like the good winter cheer never left. You can find other dorm room decorating ideas on this Pinterest board. 2. Invest in a light therapy box Similar to above, if you live somewhere cold getting enough of the suns rays can make or break your winter blues. Unless youre fortunate enough to live in the sunshine state this time of year, you may want to invest in a light therapy box for your desk.  Mayo Clinic  has some helpful information on how theyre used to treat SAD (Seasonal affective disorder). You may also want to replenish the Vitamin D youll be missing with nutrition or supplements. 3. Break up a boring routine Yes, routines can be great, but if you feel youre falling into a winter quarter slump because of the day-to-day drudgery of classes, punctuated only by more studying and mealtimes, get out there and find something fun to break up your routine. You could join a club, apply for an internship, audition for the school play, or plan an outing with friends. Anything that gives you something exciting to look forward to is a good thing. And that, my friends, is how you win winter. Enjoy the season!

A Reflection on the Welfare Provisions

A Reflection on the Welfare Provisions Welfare is the provision of necessary supports- be it monetary, social, or otherwise, for people who lack the current means to support their basic needs. The main goal of welfare is to aid those who do not have the ability to meet these needs with the income that they are currently earning. This welfare is usually provided by the government and takes form in different programs and policies. The social welfare system mainly addresses the social problems of poverty, disability, and the economic disparity that is found between the middle and upper classes and the lower class population. Economic welfare impacts the poor in many different ways by aiming to close the gap between where an individual is currently living financially and the level needed to support basic human needs. Programs such as TANF, food stamps, and housing and childcare vouchers are mainly aimed to help those living in poverty as they are need based programs. In order for an individual or family to be able to participate in these programs, they need to meet certain criterion that are based on poverty and financial aid. One issue directly stemming from this is that these programs are not available for those families deemed to be living above poverty. For those just above the need requirements for welfare programs, they may still be struggling to make ends meet but are not able to receive any governmental aid. This brings about the question of how we define poverty and the poverty line. Should those living above poverty but still struggling be able to receive financial aid? Does this require a shi ft in how we define the poverty line? Social welfare programs to aim to lessen the percentage of people living in poverty, but it’s important to consider just how successful different programs are. Social welfare is defined mainly as â€Å"direct public provision of cash and in-kind benefits to individuals and families, free or at below market cost† (Abramovitz). This system is often thought of as only serving to help poor people, but what many don’t realize is that its reach goes far beyond that. There are many social welfare programs that benefit middle and upper class people, and these programs are often seen to receive more federal funding and less stipulations than those that serve the lower class. Middle class and wealthy families do benefit from welfare in many ways. In 2000, the government spent more than 3 times as much funding on programs that do not require poverty or other need as a specification in order to receive aid than on the programs that did directly affect those living in poverty. There are many reasons for the disparity in funding- one main one being that there is a larger number of people living above the poverty line than those living at or below it. This difference also stems from the fact that program requirements for inclusion are normally less restrictive for those programs that benefit the middle and upper classes. These differences are highlighted in the U.S. House Committee on Way and Means’s comparison of disparities in average monthly cash benefits of individuals in welfare programs. This report looked at social security and public assistance as the two main categories of welfare programs, then focusing in on benefits per person. Retired worke rs received about $800 per month from social security while a family of 3 received $420 per month from TANF. This is just one disparity that helps us to see where society places its values. Historically, US policies and programs have treated those in the working class as more deserving of aid than people without jobs and single mothers. There’s a severe discrepancy in how we view those with and without jobs- often including an assumption that people without jobs are simply lazy and that single mothers are undeserving recipients because of their marital status. Social insurances are based on an individual’s prior earnings and â€Å"payroll contributions† (Marx) while public assistance is based on financial need. Social insurances such as social security are universal programs because they do not have a need-based criterion in order to participate. The latter is what is most commonly referred to as welfare, with much of the general public not recognizing that prog rams such as social security are also social welfare programs. Welfare benefits people of all classes in a multitude of ways. Society has, historically, looked down on welfare because it is seen as serving only those living in poverty. This fails to realize that the middle and upper classes also benefit from welfare programs, and that these programs are usually better funded than those serving the poor population. The social welfare system is expansive and aims to help people of all different financial levels.

The Economy and it's Effect on Politics Essay Example | Topics and Well Written Essays - 500 words

The Economy and it's Effect on Politics - Essay Example The existence of the EU is the result of desire to create a European common market, where trade barriers are removed and hence promote economic activities between political member states whilst becoming a united political entity on the world stage. Five economic tests were set out to determine whether the UK's economy was ready for such a change, 1) Convergence with the Euro zone; 2) Flexibility to adapt; 3) Impact on jobs and economic growth; 4) Impact on the financial services sector; and 5) Impact on investment (BBC, 2003). Two of these tests will be discussed in this essay. The Bank of England currently sets the interest rate for the UK but convergence means that power will be transferred to the European Central Bank (ECB). The UK's economy would have to be in sync with the rest of the Euro zone to avoid stresses on the domestic economy, for example The UK's mortgages are unlike the majority of Euro mortgages as they are in general variable rate mortgages, the UK has the highest property owner occupation than any other European country so is sensitive to interest rate changes. There are political and economic consequences to this sensitivity for example mortgage borrowers show unenthusiastic attitude to their political pee rs concerning joining the Euro zone precisely because of this and convergence would bear consequence on the economy as there would be a reduced spending power of these borrowers. Joining a single

Strategic Plan as a Crucial Part of Dynamics of Transforming Technolog Coursework

Strategic Plan as a Crucial Part of Dynamics of Transforming Technology - Coursework Example In a broader sense, strategic planning is a decision-making activity. Every organization has certain systems of strategic planning, whether implied or unambiguous. The core of the strategic plan lies in developing the right future for organizations and to accomplish competitive advantage over other rivals. Formal strategic planning in the present age is a recent phenomenon of a rapidly changing environment. Nowadays, as information technology serves as the motivator of several organizational renovations, there is an increased pressure on organizations to address their strategic planning in keeping with the upgraded technological benefits. Success usually takes place when an organization is capable of accomplishing resemblance between technology and strategic planning. The strategic planning is intended to ensure that technological activities are properly associated with the growing requirements and strategies of an organization. In present days, several organizations attempt to maint ain that technology as well as strategy is incorporated with a clear understanding of business direction. Organizations accomplish a high degree of consonance between business priorities and technological functions through better strategic configuration. In the changing technological environment, the position of strategic planning with technological activities has become one of the topmost matters for any business.In present days, the use of technology can directly impact on the competitive position in an organization. Technology has become a new weapon for organizations to develop competitiveness, indicating a new connection between business strategy and technological improvement. The competitive advantage of strategic planning based on technology can be observed from the business plan of Beach Bum gym where the use of ‘Netpulse’ technology can enhance the entertainment related experience of the members within the gym, making it one of the most competitive facilities a mong other gym clubs. It can bring about fundamental changes in the gym industry by providing customers to design their own workout environment according to their suitability.

Systemic Lupus Erythematosus Essay Example for Free

Systemic Lupus Erythematosus Essay Systemic lupus erythematosus (SLE) is a chronic inflammatory disease which may affect many different organs and tissues in the body. Women of child bearing age are typically affected, but individuals of any age, sex, or race may develop the disease. SLE while uncommon, is not rare, with an estimated disease prevalence of 1 in every 2,000 population. It is a condition which appears to be increasing in prominence especially over the last 15 to 20 years. This is likely explained by the earlier recognition of milder cases because of increased patient and physician awareness and by the enhanced availability of sensitive laboratory tests helpful in the diagnosis. Although the exact cause is not known, most of the features of the disease seem to be due to a fundamental abnormality of the bodys immune system. The immune system is the bodys defence mechanism against foreign substances entering the body. It depends on the formation of compounds called antibodies and on hite cells called lymphocytes which rise to the defense of the body in case of invasion by foreign agents such as germs or viruses. This is a normal and desirable process in the healthy individual. In patients with SLE, there seems to be a defect in the bodys immune system whereby antibodies are mistakenly formed against the bodys own tissues. This leads to inflammation and damage in the tissues so affected. Patients with SLE can be identified by the presence of these abnormal antibodies in their blood stream. It is not clear what triggers this immune abnormality but several factors seem to be contributory in some patients. These include infection, hormonal, genetic, and unidentified environmental factors. Some drugs including those used for the treatment of tuberculosis (isoniazid), high blood pressure (hydralazine), and convulsions (dilantin) have also occasionally been associated with the development of SLE. Clinical Features The majority of patients with SLE have very mild symptoms which can be easily controlled with simple measures. A small minority have more serious manifestations which may require more aggressive forms of treatment. The seriousness of the disease is frequently related to the type and number of organs affected. The following is a summary of some of the signs and symptoms that may occur in lupus patients grouped according to the organs or tissues affected: General symptoms Fever and unusual fatigue occur in up to 80 or 90% of SLE patients at some time during the course of their illness. Skin rash a very common feature occurring in many patients. The classic rash is called a butterfly rash because it occurs in a butterfly-like patch over the bridge of the nose and cheeks. This type of rash is in fact quite uncommon with most lupus rashes being far less specific and occurring anywhere on the body but especially over sun exposed areas. Many lupus rashes appear to be provoked or aggravated by direct sun exposure. Sores may also occur in the nose and mouth, and scalp hair loss may occur in some individuals. In a closely related condition called discoid lupus erythematosus (DLE), the rash may arise as distinct scaly and reddish patches which may heal with scarring. Patients with DLE are frequently otherwise well. They demonstrate few, if any, of the symptoms of SLE and usually have a nearly normal laboratory profile. Joints stiffness, pain, and swelling may commonly occur. Unlike rheumatoid arthritis however, permanent damage to the joints is almost unheard of. Membranes of the heart and lungs, the linings of the heart and lungs may occasionally become inflamed in SLE patients leading to sharp chest pains and shortness of breath. If it involves the lung, the condition is called pleuritis. If it affects the heart, the condition is called pericarditis. Blood cells a number of abnormalities may occur in the blood including anaemia or a fall in the red blood cell count and/or falls in the white cell count or platelet count (particles in the blood that help with clotting) and thus lead to potential problems with bleeding. Kidneys often a sign of more serious disease, inflammation of the kidney may lead to loss of protein in the urine, increased blood pressure and occasionally kidney failure. Brain and nerves fortunately, a relatively rare problem, patients so affected may have trouble with headaches convulsions, emotional disturbances, weakness or numbness of the extremities. Diagnosis The diagnosis of SLE is suspected in any individual who presents with one or more of the clinical features outlined above. A diagnosis is confirmed by laboratory tests which show the presence of one or more abnormal circulating antibodies in the blood stream. These antibodies may be directed against any tissue in the body. The most important of these however, is an antibody directed against the centre or nucleus of the cells in the body, the so-called anti-nuclear antibody or ANA. ANAs are normally not present or present only in barely detectable quantities in healthy individuals. Thus, this test is very helpful to the doctor if he is suspicious about the possibility of SLE. It is very important however, to stress that the presence of ANAs doesnt specifically point to a diagnosis of SLE since abnormal antibodies of this type may occur in other conditions such as rheumatoid arthritis, certain infections and inflammation of the liver. Thus the diagnosis of SLE requires both the presence of abnormal antibodies (especially ANAs) as well as signs and symptoms suggesting inflammation of several organs or tissues in the body. Although, all lupus patients have elevated levels of ANA, not all people with elevated ANA have lupus. Increased levels of ANA generally indicate that the physician should follow up with an anti-DNA antibody test. To assist in the diagnosis of SLE, the American Rheumatism Association (ARA) in 1982 adopted a set of criteria for the classification of this disease. (See Table 1) It should be noted that while a variable number of these features may occur during the course of the disease, they need not occur at the same time. Moreover, it is quite unpredictable as to which patient may develop which particular symptom or grouping of symptoms at any particular time.

Othello, The Moor of Venice Essay examples -- Shakespearean Literatur

Othello, the Moor of Venice is one of the major tragedies written by William Shakespeare that follows the main character, Othello through his trials and tribulations. Othello, the Moor of Venice is similar to William Shakespeare’s other tragedies and follows a set of specific rules of drama. The requirements include, following the definition of a tragedy, definition of tragic hero, containing a reversal of fortune, and a descent from happiness. William Shakespeare fulfills Aristotle’s requirements in this famous play. Aristotle the famous philosopher outlined several requirements in which a play or piece of drama is to follow. The first rule that is met in Shakespeare’s play is that Othello is considered tragic hero, which every tragedy must contain. According to Aristotle, the tragic hero must be a man in a position of power who is a good person and makes a mistake during the timeline of the play due to a tragic flaw. Othello’s major flaw can be seen as jealousy: â€Å"Othello has often been described as a tragedy of character, as the play’s protagonist swiftly descends into a rage of jealousy that completely destroys his life†("Othello"). Othello is shown he is a good man within the first few scenes of the play: â€Å"She wished she had not heard it; yet she wished That heaven had made her such a man† (1.3.162-163). This line in Act I spoken by Othello, is an indication that he is a good person although it may appear that he has stolen Desdemona away from her father. Othello speaks that although he has taken Desdemona as his wife without Brabantio’s consent, he is a good person for stating his reasons for his actions as well as standing his ground. After Othello’s marriage to Desdemona, the conflict is started when Iago insinuates t... ... Works Cited Catherine Bates, "Weaving and Writing in Othello," in Shakespeare Survey, Vol. 46, edited by Stanley Wells, Cambridge University Press, 1994, pp. 51–60. Dreher, Diane. "Shakespeare's Cordelia and the power of character." World and I Apr. 1998: 287+. Fine Arts and Music Collection. Web. 11 Dec. 2011. Newton, K.M. "Othello: Overview." Reference Guide to English Literature. Ed. D. L. Kirkpatrick. 2nd ed. Chicago: St. James Press, 1991. Literature Resource Center. Web. 11 Dec. 2011. "Othello." Shakespeare for Students: Critical Interpretations of Shakespeare's Plays and Poetry. Ed. Anne Marie Hacht. 2nd ed. Vol. 2. Detroit: Gale, 2007. 649-687. Gale Virtual Reference Library. Web. 11 Dec. 2011. Shakespeare, William. Othello, the Moor of Venice. Literature. Boston: Bedford/St. Martins, 2009. 368-455. Print. Othello, The Moor of Venice Essay examples -- Shakespearean Literatur Othello, the Moor of Venice is one of the major tragedies written by William Shakespeare that follows the main character, Othello through his trials and tribulations. Othello, the Moor of Venice is similar to William Shakespeare’s other tragedies and follows a set of specific rules of drama. The requirements include, following the definition of a tragedy, definition of tragic hero, containing a reversal of fortune, and a descent from happiness. William Shakespeare fulfills Aristotle’s requirements in this famous play. Aristotle the famous philosopher outlined several requirements in which a play or piece of drama is to follow. The first rule that is met in Shakespeare’s play is that Othello is considered tragic hero, which every tragedy must contain. According to Aristotle, the tragic hero must be a man in a position of power who is a good person and makes a mistake during the timeline of the play due to a tragic flaw. Othello’s major flaw can be seen as jealousy: â€Å"Othello has often been described as a tragedy of character, as the play’s protagonist swiftly descends into a rage of jealousy that completely destroys his life†("Othello"). Othello is shown he is a good man within the first few scenes of the play: â€Å"She wished she had not heard it; yet she wished That heaven had made her such a man† (1.3.162-163). This line in Act I spoken by Othello, is an indication that he is a good person although it may appear that he has stolen Desdemona away from her father. Othello speaks that although he has taken Desdemona as his wife without Brabantio’s consent, he is a good person for stating his reasons for his actions as well as standing his ground. After Othello’s marriage to Desdemona, the conflict is started when Iago insinuates t... ... Works Cited Catherine Bates, "Weaving and Writing in Othello," in Shakespeare Survey, Vol. 46, edited by Stanley Wells, Cambridge University Press, 1994, pp. 51–60. Dreher, Diane. "Shakespeare's Cordelia and the power of character." World and I Apr. 1998: 287+. Fine Arts and Music Collection. Web. 11 Dec. 2011. Newton, K.M. "Othello: Overview." Reference Guide to English Literature. Ed. D. L. Kirkpatrick. 2nd ed. Chicago: St. James Press, 1991. Literature Resource Center. Web. 11 Dec. 2011. "Othello." Shakespeare for Students: Critical Interpretations of Shakespeare's Plays and Poetry. Ed. Anne Marie Hacht. 2nd ed. Vol. 2. Detroit: Gale, 2007. 649-687. Gale Virtual Reference Library. Web. 11 Dec. 2011. Shakespeare, William. Othello, the Moor of Venice. Literature. Boston: Bedford/St. Martins, 2009. 368-455. Print.

Paritcipation in Team Sports Essay

PARTICIPATION IN TEAM SPORTS FOSTERS THE DEVELOPMENT OF THE INDIVIDUAL The participation in team sports fosters the development of the individual. Not only giving a person an excuse to exercise, team sports have a few other benefits as well for example social, emotional and physical ones. The participation in team sports is important to the development of the individual. It helps your physical and emotional growth and builds valuable social skills. It also helps to build ones character, develops your people skills, teaches perseverance and develops your integrity, giving you moral fibre. Being part of a team you will have to sacrifice and it asks for a great deal of commitment and perseverance. Giving up on spending time in front of the television and spending it at practise is vital for any team’s success. The fact that you have your teammates around you makes the difficult task of sacrifice and attending every practise very easier as you are there to motivate each other. â€Å"I am a member of a team, and I rely on the team, I defer to it and sacrifice for it, because the team, not the individual, is the ultimate champion†- Anonymous Team sports provide an opportunity to learn discipline, confidence and leadership. It teaches principles such as tolerance, co-operation and respect. Above all it teaches the value of effort and how to manage victory as well as defeat. It will help the individual to also be happy for other player’s successes because they see how it benefits the greater team. The individual will appreciate fair play in their team sport. Playing team sport is the easiest way to stay fit and healthy and still enjoy doing this. Team sport fosters the development of a healthy lifestyle. It is possible to stay fit and healthy playing any sport, but once again having that friend next to you, motivating you through the last twenty metres can definitely not be replaced by any accomplishment in an individual sport. Being part of a team, especially across different cultural barriers can develop and build your character. A team sport can instill core values in an individual, such as, co-operation, sharing and respect. It helps a person connect with others and accept each other for who they are, despite the fact of being different and making mistakes on the field. To be an individual on the sports field can never beat the sensation of belonging to a team. That is why I know that the development of an individual can only increase in a team sport. As we have all heard so many times: There is no â€Å"I† in team. Working together is fun. So, join the team and develop every aspect of your life, while having fun and not being lonely and all by yourself.

Karl Benz Essay

Karl Benz was born on 25th November 1844 in Karlsruhe, the son of an engine driver. The middle of the last century, when Benz was an apprentice, was a time of widespread fascination with the â€Å"new technology†. The first railway line in Germany from Nuremberg to Furth had been opened in 1835, only twenty years before, and in the space of just a few decades the railways, steamships and new production processes had ushered in a new era in technology, industry and everyday life. Karl Benz attended the Karlsruhe grammar school and subsequently the Karlsruhe Polytechnic. Between 1864 and 1870, he worked for a number of different firms as a draughtsman, designer and works manager before founding his first firm in 1871 in Mannheim, with August Ritter. But little money was to be made in the building materials trade and the economic convulsions of the 1870’s caused difficulties for the young company. Karl Benz now turned to the two-stroke engine, in the hope of finding a new livelihood. After two years’ work, his first engine finally sprang to life on New Year’s Eve, 1879. He took out various patents on this machine. Equally important were the contacts with new business associates, with whose assistance Benz founded a gas engine factory in Mannheim. But after only a short time he withdrew from this company since it did not give him a free enough hand for his technical experiments. Benz found two new partners and with them founded â€Å"Benz & Co., Rheinische Gasmotorenfabrik† in 1883 in Mannheim, a general partnership. Business was good and soon the production of industrial engines was being stepped up With this new financial security, Karl Benz could now set about designing a â€Å"motor carriage†, with an engine based on the Otto four stroke cycle. Unlike Daimler, who installed his engine in an ordinary carriage, Benz designed not only his engine, but the whole vehicle as well. On 29th January 1886, he was granted a patent on it and on 3rd July 1886, he introduced the first automobile in the world to an astonished public. In 1903, Karl Benz retired from active participation in his company. The next year however, he joined the supervisory board of Benz & Cie and he was a member of the supervisory board of Daimler-Benz AG from 1926, when the company was formed, until his death in 1929. In 1872, Karl Benz married Bertha Ringer, who was to be of major support to him in his work. The couple produced five children. Benz lived to witness the motoring boom and the definitive penetration of his idea in to everyday life. He died on 4th April 1929. The former Benz family residence in Ladenburg is now open to the public. The Daimler-Benz foundation, founded in 1986, has its registered office here.

Kobe Earthquake Essays - Seismology, Great Hanshin Earthquake

Kobe Earthquake Essays - Seismology, Great Hanshin Earthquake Kobe Earthquake An earthquake is defined as a shaking or trembling of the earth that is volcanic or tectonic in origin. In the case of the Great Hyogo (Hanshin) earthquake of Kobe, Japan it is tectonic in origin. This devastating earthquake which occurred on the 17th of January at 5:46 a.m measured at a whopping 7 (7.2) on the Richter scale. This was the largest recorded earthquake to ever hit Japan. According to the Japan Meteorological its epicentre was in 34.6 north and 135.0 east in the northern tip of Awaji Island with a focal depth of 14 km. According to the results of the recorded in 24 observation centre, the fracture which triggered the earthquake was happened inside the Nojima Fault. Also investigation in the sea bed by the Ocean observatory Centre shows that the cracks occurred in Nojima Fault. This fault forms a part of a group of faults known as the Rokko Fault', which extends from Awaji Island through Kobe City to the foot of Mount Rokko. The movement of the fault can be explained by the Tectonic characteristic of west Japan. The main reason for the big earthquakes in west part of Japan are the tectonic activities of the Eurasian, the Pacific, the North America and the Philippine plates. The collision between these plates in the central part of Honshu (Japan main island) is the main source of strain accumulation in the crust of western part of Japan. Casualty figures quickly mounted by the hour and when it was all said and done 5,472 people had lost their lives and 415,000 people were left injured. By the fourth day after the earthquake about 310,000 residents spent the night at 1,077 refugee centres. More than 350 fires broke out wiping out around 100 hectares of densely populated area. Fire fighting was virtually ineffective due to an inadequate water supply and access to fires. Lifeline facilities were severely damaged over a large area and following the earthquake, 900,000 households were left without electricity, 850,000 households were without gas, and water supply cuts affected about 2.5 million people. Nippon Telegraph and Telephone (NTT) Corp.'s 160,000 lines out of 800,000 lines were out of order. The damage to major infrastructure, especially to the elevated expressway and shinkansen (bullet train) tracks, shocked engineers, planners and the general public. According to news reports its tracks were damaged at 42 locations. The first Shinkansen train was to run 30 minutes after the time of the earthquake. Had the disaster occurred few hours later, with an average capacity of about 1,600 passengers/train, casualty rate could have been much higher. Sections of elevated Hanshin expressway toppled virtually cutting off major transport lines to the affected areas. A contiguous section supported by eighteen single columns had fallen sideways in Higashi Nada-ku. Modern buildings and structures retrofitted with up-to-date engineering techniques fared well in the Great Hyogo quake. Much of the damage occurred in traditionally built older homes and in areas near the coast where liquefaction of the soil caused instability in structures. A large number of reinforced concrete structures were completely devastated. The economic damage estimates vary from around 100 - 150 billion dollars US. The most extensively and severely damaged structures were smaller commercial buildings (often with residences upstairs) constructed with limited engineering design and traditional homes. The smaller commercial and mixed occupancy buildings are typically framed with wood or light steel and have walls of stucco over wood slats. Many of these buildings have a large shop window in the front and lack interior walls, factors which weaken the first floor. Traditional homes, typically those built before the 1970s, have heavy tile roofs with tiles set in a thick clay and mud mortar, few partitions, and are not waterproofed which causes widespread dry rot and water damage. Little nailing is used; wood joinery is more common. Many casualties were found in damaged and collapsed traditional homes. The heavy tile roofs stressed the walls, which cracked, crumbled and often collapsed, triggering fires from broken gas pipes. The Kobe earthquake exposed more modern and engineered buildings to stronger forces than any previous earthquake. The preliminary report indicates more studies are needed to evaluate seismic codes, design practice and construction

The origin and justification of judicial review Essay

The origin and justification of judicial review - Essay Example Many people did not believe in giving the judiciary such powers and authority. Since the institution of the American constitution, the judicial system was given the mandate to oversight the activities of the state government. The statutes and states’ constitutions could not, under the observation of the judicial system, go against the supreme law of the land. This supreme law is the American constitution. However, one issue that the framers of the American constitution did not provide a solution for is whether the federal courts had any oversight power over the congress and the executive. Upholding congressional acts in the early years of the republic somehow confirmed the existence of judicial review. However, it was still unclear, until 1803, whether the judiciary had any power to similarly strike down the acts. In 1803, the chief justice John Marshall ruled an act of congress unconstitutional. In his argument, the duty of the Supreme Court and the judicial system is largely to declare the law. According ti him, therefore, a statutory, congressional of even executive act that is against this law must be deemed unconstitutional and the constitution must prevail. In another instance, the judicial review was applied once more before the civil war. The Supreme Court, in 1857, ruled the Missouri Compromise of 1820 unconstitutional. It is also at around the same time that several statutory acts were struck down by the Supreme Court. In addition, concerns were raised after the Civil War on the Fourteenth Amendment which gave the federal government unnecessary powers over the state governments. This being an executive was again struck down. This further confirmed the stability of the judiciary and its impartiality in applying the power bestowed on it. This exercise of power has however not been wit hout political opposition. By the end of the nineteenth century, the Supreme Court was repeatedly

HR Apple company Leadership and Motivation&Reward Essay

HR Apple company Leadership and Motivation&Reward - Essay Example Apple Computer Inc. is a company that has gained universal recognition due to its innovative and branded hardware and software that are easy to use, powerful and more elegant as compared to those of their rivals (Carlopio, Andrewartha & Armstrong 2004, p. 217). However, this positive innovation can be attributed to the leadership practices and motivation and reward that are exercised by the management team of this company. This paper will therefore critically evaluate the effect and contribution of leadership practices and motivation on the performance of Apple Computer Inc. and other organizations. For this purpose, the paper aims at providing the clear definitions of leadership and motivation and reward, thereby critically examining different theories appropriate to these practices. According to Gibb, leadership is the process of influence whereby principled and authoritative individuals exercise high level of influence over the subjects or followers than the subjects did over them (qtd in Ladkin 2010, p. 35). Gibb therefore recognized leadership as a processes in which an individual exercised due influence on another in order to complete an assigned task or to achieve a certain objective. On the other hand Marshall describes transformational leadership as the a leadership style whereby a leader identifies an absolute need for change in the organization, formulates a vision that will â€Å"guide the change through inspiration† and lastly, executes the change with the help and commitment of others (2011, p. 3). Transformational leaders therefore tend to work towards achieving extraordinary positive results. Transformational leadership theory has interested of many organizational leaders over the past few years. According to Givens, this theory was established in 1978 by Burns (2008, p. 4). This theory is based on the ability of the leader to provide motivation to the subjects in order to accomplish the general set

Short Essay Response Example | Topics and Well Written Essays - 1000 words

Short Response - Essay Example Sustainability, however, is hard to attain in urban areas, where cities with high population density equate to large production of wastes and rapid consumption of natural resources. One of the most pressing problems facing urban planners today is how to create sustainable urban communities and to bring existing non-sustainable communities to the path of sustainability. Some of the potential avenues toward solving the issue of sustainability are creating a new city that is similar to a town in walkability and closed-loop metabolism, but a global one, because of the use of technology and modern networks in attaining its sustainability goals; understanding the unique strengths and constraints of every urban community for urban planning/redesign; and incorporating ecological concepts and principles in how urban communities are perceived, which require collaboration across all main stakeholders, including the government, the business community, citizens, and other related professionals. The historical roots of these problems on sustainability are the vast industrialization across the world during the past centuries and the free-market philosophy of liberal economics and capitalism that disregard sustainability principles. Industrialization, since the eighteenth century up to now (as it goes in more in developing countries), has resulted to widespread exploitation of natural resources and workers alike (WCED 354). As the Brundtland report summarizes: â€Å"Thus today’s environmental challenges arise both from the lack of development and from the unintended consequences of some forms of economic growth† (WCED 354). In urban design, it means converting agricultural areas to manufacturing/commercial/residential/entertainment sites and creating high-rise cities where population is more compact and where resources are swiftly consumed.

The experiment safe Essay Example for Free

The experiment safe Essay In every day lives we come across a number of different objects that are bouncing, colliding and in motion. All these are attributable to the energy changes involved in the process thus obeying the law of conservation of energy. The law of conservation of energy states that energy can neither be created nor destroyed and that the sum total of energy in this universe remains constant. This scientific method of looking at energy changes can be associated and implemented on a variety of simple things and one among them being observation of bouncing objects. This motivation has lead me to investigate, understand and analyse bouncing of a ball on a surface. However, understanding the bouncing mechanism is not as simple as it appears, because there are several factors involved during the bouncing action. For example, the material of the ball, the type and nature of surface over which it freely falls, frictional factors due to air resistance, temperature affecting the surrounding air molecules as well as during the ball-surface interactions. Preliminary Investigation Looking around practically made me notice a variety of different types and sizes of balls. There were golf balls, tennis balls, footballs, sponge balls, cricket balls, bouncy balls, etc. I observed them carefully and noticed that none were similar in any way. The cricket balls were the only ones made out of leather, the bouncy balls were made out of dense rubber, and the golf balls were made of plastic. I tried to test the bounce of these balls on different surfaces like carpeted flooring and wooden flooring. I found that each ball when dropped on these flooring was bouncing to different heights. I felt that each of these balls when dropped on a given flooring surface had different factors that influenced their bounce. Also I noticed that the ball being dropped constantly bounced almost at the same height. This made me feel that I could use this as my chosen experiment for further investigations. As mentioned earlier, the bouncing of balls may look simple, but the energy conversions are quite complex. In simple terms, the work done during a bouncing ball system involves three possible energy sources, 1) Gravitational potential energy (energy due to its position) 2) Kinetic energy (energy due to its motion) 3) frictional energy (lost due to production of heat and sound). The ball acquires Gravitational Potential Energy because of its position and also the ball is working against the gravity to acquire this position. Kinetic energy is gained during the motion of the ball. The frictional energy is lost due to the production of heat and sound. In fact, the conversion of the potential energy results in the kinetic energy of motion until the bounce is over and this potential energy is regained as ball acquires the next position or height. However, on each bounce over a given surface energy of impact is transferred to the surface on which it bounces. Also energy is used up in over coming the air resistance. The energy of impact can be split into sound energy, heat energy or light energy (spark) in the case of very heavy balls (for ex. Iron balls striking iron plate surfaces). This can be totally called as frictional energy loss. The process of bouncing continues with frictional loss occurring on each bounce and this effect could be known as damping. Damping means the loss of height on each bounce on a given surface. The damping effect decreases until the ball attains the minimum potential energy. The damping effect influences the speed and so it tends to slow down the ball each time it impacts the surface. To observe this effect experiments were planned to drop large bouncy balls on different surfaces and to note the rebound heights. Preliminary Results Bounce Quality Number Balls used Carpet flooring Wooden flooring 1 Golf Ball Low Medium 2 Tennis Ball Medium Medium 3 Football Low Low 4 Sponge Ball Low Low 5 Cricket Ball Low Low 6 Bouncy Ball Medium High Below are the formulae of different types of energy and work done: Potential Energy: PE = mgh 1) Where, m= mass of the ball (kg) g= acceleration due to gravity () h= height of the bounce(m) Work Done: Wd = F x d -(2) Where,F= Force (N) d = bounce height (m) Also as part of my preliminary work I did some work using a CD Called Science Investigations. This was very useful as I could see how the ball rebound height would differ if I changed the temperature of the ball. The ball being used was a squash ball. The results I gained were as follows (assuming that the drop height was kept the same-1metre): Temperature(i C) Rebound height(cm)Â   (The rebound height was measured from the bottom of the ball. ) As you can see, these results seem fairly realistic and accurate. As the temperature inside the squash ball increased, the rebound height increased. This was the case in all of the tests. Also using this CD I could investigate the different amounts of energy bring used up when a ball bounces. A ball has 100% gravitational potential energy when it is in your hand. As soon as you release it the amount of gravitational potential energy decreases and instead, 100% Kinetic energy is formed. However, when the ball hits the ground there is no kinetic energy or gravitational potential energy. Instead, there is only elastic potential energy and heat/sound energy. After the ball hits the ground, kinetic energy is regained again, but it is not a full 100%, it is only 80%. 20% of the energy was used up as heat/sound energy. So when the ball is caught in your hand again, the gravitational potential energy returns, but there is only 20% of what there previously was, so the ball does not reach its drop height. Safety: To make the experiment safe, I will have to make sure of the following: That the nail that supports the ball is tightly secured in its position. That the balls are used in a proper manner in all situations. The equipment like the clamp and stand are fixed to the workbench securely. To make this test fair I will have to make sure of the following: That the metre rule is straight and not at an angle. That I release the ball from the given point. E. g. Place the bottom of the bouncy ball in line with the one metre mark, the 0. 8 metre mark etc. Just release the ball without adding any extra force. Keep the temperature in the room constant. Make sure that there is very little air movement. Make sure that you have the same experimental conditions for all the three trials. The factor I will be investigating is the height I drop the ball.

Structure and Uses of Ibuprofen

Structure and Uses of Ibuprofen Abstract The Controlled-release dosage forms are formulated to release the drugs active ingredient gradually and predictably over an extended period of time that is something like 12 to 24 hour period. â€Å"These formulations potentially provide for greater effectiveness in the treatment of chronic conditions through more consistent delivery of the medication; reduced side effects; greater convenience; and higher levels of patient compliance due to a simplified dosage schedule, compared with those of immediate-release drugs†. Ibuprofen is a colourless, crystalline solid which is having a low soluble limits in water but it is having a better solublity in most organic solvents. â€Å"The main aim of this work is control the release of drug by encapsulating it in to coating materials like fattyacids (palmiticacid and pluronic F-127). Encapsulating of ibuprofen by using freeze drying technique in this technique Ibuprofen is encapsulated in to the fattyacid and pluronic (F127), these coating materials have the property of controlling the release of drug when the coated drug is entered in to the body the coating materials which surrounded to the drug is control the release of drug†. The release of encapsulated ibuprofen is determined by Flow through dissolution and UV- visible spectroscopy. INTRODUCTION 1. IBUPROFEN Ibuprofen is a colourless, crystalline solid which is having a very very low solubility limits I case of water but it is having comparabelly better soluble limits in case of organic solvents. The synthesis of ibuprofen was originally reported in 1964 from Ï -isobutyl- lacetophen but the drug was not marketed in the United States until 1974 despite the fact that it had been available for several years in Europe. â€Å"It was the indomethacin and was immediately accepted in therapy. Its success was a factor in the introduction of many new agents in the 1970s. Ibuprofen was the first aryl propionic acid derivative to be marketed in the United States†. This chemical class currently comprises of the largest group of NSAIDs under investigation with as many as 25 derivatives in various stages of development. â€Å"It recently became the first prescription NSAIA to become available as an over the counter analgesic in almost 30 years and is avialble under a number of trade names, It is also sometimes known as: Advil, Anadin Ibuprofen, Arthrofen, Brufen, Retard, Cuprofen, Fenbid; Galprofen, Hedex Ibuprofen, Ibufem; Librofem; Mandafen; Manorfen; Migrafen; Motrin; Nurofen; Obifen; Relcofen perhaps being among the more widely used. The continuing popularity of ibuprofen is evidenced by the appearance 200 prescription drugs in the United States†. IUPAC name : 2-[4-(2-methylpropyl) phenyl] propanoacid, Formula : C13H18O2, Molecular mass : 206.28, Melting point : 76  °C (1. 69  °F) Bioavailability : 49-73, Protein binding : 99%, Metabolism : Hepatic, Half life : 1.8-2 hours, Excretion : Renal. 1.1 Structure of Ibuprofen Structure of IBUPROFEN Ibuprofen is a white powder belonging to the propionic acid derivatives, with a melting point of 74 77 ° C. It is only slightly soluble in water but readily soluble in organic solvents such as ethanol. It is a chiral compound; racemic Ibuprofen is usually used, although only one form is active medicinally. â€Å"Ibuprofen is made up of covalently-bonded carbon, hydrogen, and oxygen atoms. 2 CH3 molecules are single-bonded to a CH molecule The CH molecule is bonded to a carbon atom that forms a 6-sided ring of carbon atoms†. Another CH molecule is single-bonded to a carbon atom on the other side of the ring. Inside the ring there are 3 double bonds between carbon atoms. Then another CH3 molecule and a COOH molecule are both single bonded to the CH molecule on the right. Because it is nonsteroidal, it is widely used as it does not upset the hormonal balance in the body. Its anti-inflammatory, analgesic (pain relieving) and antipyretic (fever reducing) actions are co moderate pain such as headache, toothache, and migraine as well as symptoms of fever. 1.2 Stereochemistry Ibuprofen contains a chiral carbon in the ∞ position of the propionate moiety. As such, there are two possible enantiomers of ibuprofen, with the potential for different biological effects and metabolism for each enantiomer. Indeed it was found that (S)(+)- ibuprofen (dexibuprofen) was the active form both in vitro and in vivo, because of this reason the ibuprofen is marketed as a single enantiomer as occurs with naproxen and other NSAIDs. And the in vivo experiments revealed the existence of an Isomerase (2-arylpropionylco-A epimerase) which converted (R) -ibuprofen to the active (S)-enantiomer .Most of the ibuprofen formulations are marketed as racemic mixtures. Racemic ibuprofen is an important NSAID used in the treatment of pain and inflammation in a variety of musculoskeletal rheumatic disorders. 1.3 Synthesis â€Å"There have been many commercial and laboratory publications for the synthesis of Ibuprofen. Two of the most popular ways to obtain Ibuprofen are the Boot process and the Hoechst process. The Boot process is an older commercial process developed by the Boot Pure Drug Company, and the Hoechst process is a newer process developed by the Hoechst Company. Most of these routes to Ibuprofen begin with isobutyl benzene and use Friedel-Crafts acylation. The Boot process requires six steps, while the Hoechst process, with the assistance of catalysts, is completed in only three steps†. Cheminor Drugs have developed a process for an improved version of ibuprofen based on chiral synthesis. The move is significant given that pure S-Ibuprofen (the active form of ibuprofen) could near halve the regular ibuprofen dosage, besides improving the side-effect profile. However the human body can convert the inactive (R) form into the (S) form, so eventually 100% of the ibuprofen taken becomes active. The process discovered by Cheminor is therefore unlikely to have commercial significance. [6] 1.4 Mechanism of action: â€Å"Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variants of cyclooxygenase (COX-1 and COX-2). Ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity is achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa†. The role of the individual COX isoforms in the analgesic, anti-inflammatory, and gastric damage effects of NSAIDs is uncertain and different compounds cause different degrees of analgesia and gastric damage. 1.5 Absorption and metabolism: Ibuprofen is quite rapidly absorbed when it is admistered orally we can witness the peak plasma levels are obtained withan 2hours time.† As with most of these acidic NSAIDs , ibuprofen(pka=4.43) is extensively bound to the plasma proteins(99%) and will interact with other acidic drugs which are protein bound. Metabolism occur rapidly and the drug is nearly completely excreted in the urine as UN changed drug and oxidative metabolites with in 24 hrs following administration†. Metabolism involves primarily ω-1and ω-2 oxidation of the Ï -iso butyl side chain, followed by alcohol oxidation of the primary alcohol resulting from the ω-oxidation to the corresponding carboxylic acid. All metabolites are essentially in active. When Ibuprofen id administered as the individual enantiomers, the major metabolites isolated are the (+)-isomers regardless of the configuration of the administered enantiomer.intrestingley, the (R)(-)-enantiomer is inverted to the (S)-(+)-enant iomer in vivo, accounting for the observation that the two enantiomers are bioequivalent In vivo. 1.6 Ibuprofen uses: Ibuprofen is used to relief the symptoms of a wide range of illnesses such as headaches, backache, period pain, dental pain, neuralgia, rheumatic pain, muscular pain, migraine, cold and flu symptoms and arthritis. Recently evidence has emerged suggesting that ibuprofen is effective in the treatment of Alzheimers disease. 1.7 Ibuprofen side effects Ibuprofen is regarded as the first choice drug in its class due to the low number of side effects and complications associated with it. The most frequent type of adverse reaction occurring with ibuprofen is gastrointestinal. In clinical trials, the percentage of patients reporting one or more gastrointestinal complaints ranged from 4% to 16%. Common Side Effects: stomach upset or irritation Infrequent Side Effects: nausea and/or vomiting, constipation, diarrhoea Rare Side Effects: skin irritations, drowsiness, gastrointestinal bleeding Ibuprofen has the lowest incidence of gastrointestinal adverse effects, reactions of all the non selective NSAIDS. However this only holds true in case of lower doses of ibuprofen, so over the counter preparation of ibuprofen are generally labelled to advise a maximum daily dose of 1,200 mg. 1.8 Risks involved 1.8.1 Cardiovascular Risk: Along with several other NSAIDs, ibuprofen has been implicated in elevating the risk of myocardial infarction, particularly among those chronically using high doses. 1.8.2 Risks in Pregnancy: Ibuprofen consumption should be avoided in late pregnancy due to risk of premature closure of the ducts arteries in the fetal heart. 1.8.3 Risks in Inflammatory Bowel Disease â€Å"Ibuprofen should not be used regularly in individuals with Inflammatory Bowel Diseas (IBD-Crohns Disease and Ulcerative Colitis)due to its ability to cause gastric bleeding and form ulceration in the gastric lining. Drugs such as Advil should be avoided in persons afflicted with IBD. Pain relievers such as Tylenol (containing acetaminophen) or drugs containing Codeine (which slows down bowel activity) are safer methods than Ibuprofen for pain relief in IBD†. Ibuprofen is also known to cause worsening of IBD during times of a flare-up, thus should be avoided completely. 1.8.4Drug-Drug Interactions Ibuprofen is associated with several suspected or other probable interactions that can affect the action of other drugs .Ibuprofen leads to the increased levels of lithium leading to the reduction of lithium excretion from the kidneys, and this may lead to lithium toxicity. Ibuprofen may lead to the lowering of blood pressure because prostaglandins play an important role in reducing the blood pressure. Ibuprofen is used in combination with amino glycosides for e.g.: The blood levels of gentamycin may increase presumably because the elimination of amino glycosides from the body is reduced and may lead to amino glycoside side effect. 1.9. Absorption and Metabolism Ibuprofen is rapidly absorbed on oral administration with peak plasma levels being generally attained with in 2hrs. As with most of these acidic NSAIDs , ibuprofen(pka=4.43) is extensively bound to the plasma proteins(99%) and will interact with other acidic drugs which are protein bound. Metabolism involves primarily ω-1and ω-2 oxidation of the Ï -iso butyl side chain, followed by alcohol oxidation of the primary alcohol resulting from the ω-oxidation to the corresponding carboxylic acid. All the metabolites are essentially inactive. The (R)(-)-enantiomer is inverted to the (S)-(+)-enantiomer in vivo, accounting for the observation that the two enantiomers are bioequivalent In vivo. 1.9 Mechanism of Action Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. Prostaglandins are produced in response to injury or certain diseases 2 variants of cyclooxygenase (COX-1 and COX-2). Ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity is achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa. The role of the individual COX Isoforms in the Analgesic, Antiinflammatory, and the Gastric damage and affects of NSAIDs is uncertain and different degrees of Analgesia and Gastric damage occur. 1.10 Controlled Release Mechanisms Controlled release implies regulation of the delivery of a a drug by a device the control is aimed at delivering the drug at a specific rate for a definite period of time independent of the local environments. Controlled release may also incorporate methods of promote localization of drug at an active site. Site specific and targeted delivery systems are the descriptive term used to denote this type of control. The periods of delivery are much longer than in case of sustained release and may vary from days to years. Controlled release mechanism is designed to release the drug in vivo according to predictable rates that can be verified by in-vitro measurements. Controlled release technology implies a quantities understanding of the physic chemical mechanism of drug availability to the extent that the dosage form release rate can be specified. Potential development s and new approaches to oral controlled release drug delivery systems, intragastric floating tablets, Trans mucosal tablets and micro porous membrane coated tablets . An example of application to the controlled release technology to dosage form design consists of a polymer matrix in which a drug containing solution is dispersed in the form of micro cells. The barrier permeability and the drug solubility in the dispersed solution are variables that can be adjusted to provide predictable drug release rates. All pharmaceutical dosage forms should be controlled release formulations -with rate specified and bioavailability assured by the drug delivery design. There are three types of controlled release mechanisms: Ø Diffusion Ø Swelling Ø Degradation 2 .Palmitic acid Palmitic acid,CH3(CH2)14COOH or hexadecanoic acid in IUPAC nomenclature, is one of the most common saturated fatty acids found in animals and plants. As its name indicates, it is a major component of the oil from palm trees (palm oil and palm kernel oil). Palmitate is a term for the salts or esters of palmitic acid. The palmitate anion is the observed form of palmitic acid at physiological pH. CAS number 57-10-3 Molecular formula C16H32O2 Molar mass 256.42 g/mol Appearance White crystals Density 0.853 g/cm3 at 62  °C Melting point 63-64  °C Boiling point 351-352  °C[2] 215  °C at 15 mmHg Solubility in water Insoluble 2.1 Biochemistry â€Å"Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced. Palmitate negatively feeds back on acetyl- CoA carboxyl(ACC) which is responsible for converting acetyl-CoA to malonyl-CoA which is used to add to the growing acyl chain, thus preventing further palmitate generation. Reduction of palmitic acid yields cetyl alcohol†. 2.2 Uses Derivatives of palmitic acid were used in combination with naphtha during World War II to produce napalm (aluminum naphthenate and aluminum palmitate). [6] â€Å"The World Health Organization claims there is convincing evidence that dietary intake of palmitic acid increases risk of developing cardiovascular diseases. However, possibly less-disinterested studies have shown no ill effect, or even a favorable effect, of dietary consumption of palmitic acid on blood lipids and cardiovascular disease, so that the WHO finding may be deemed controversial.[8] However, another study showed that palmitic acid has no hypercholesterolaemic effect if intake of linoleic acid is greater than 4.5% of energy. On the other hand, it was shown that, if the diet contains trans fatty acids, the health effects are negative, causing an LDL cholesterol increase and HDL cholesterol decrease†. â€Å"Recently, a long-acting anti-psychotic medication, paliperidone palmitate (marketed as INVEGA Sustenna), used in the treatment of schizophrenia, has been synthesized using the oily palmitate ester as a long-acting release carrier medium when injected intramuscularly. The underlying method of drug delivery is similar to that used with decanoic acid to deliver long-acting depot medication, in particular, neuroleptics such as haloperidol decanoate†. 3 .Pluronic F-127 Pluronic F127 is a difunctional block copolymer surfactant terminating in primary hydroxyl groups. A non-ionic surfactant that is 100% active and relatively nontoxic. 3.1 Specifications Cloud point (10% aqueous)†¦.. >100 °C Color, APHA †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 120 max. Water, weight %†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. Cast Solid-0.4 max. Prill/Micropastille-0.75 max. pH (2.5% aqueous)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 6.0 7.0 3.2 Typical physical properties Form†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. Cast solid /Prill /Micropastille Average molecular weight†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦ 12600 Specific gravity, 77 °/25 °C†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 1.05 Viscosity, cps at 77 °C †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 3100 Melt Point†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. 56 °C Cloud point (1% aqueous)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦ >100 °C Foam height (Ross Miles, 0.1% aqueous at 50 °C)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 40 mm Surface tension (0.1% aqueous)†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 41 dynes/cm at25 °C HLB†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ 18 − 23 Solubility in water at 25 °C†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. >10% Wetting, Draves Sink Time (3-gm hook, 0.1% aqueous at 25 °C)†¦.. >360 seconds â€Å"Pluronicf-127 is polymer with an additional property in aqueous solution which will covert from its liquid state to that of a non fluid hydrogel, which is a main characteristic of the protein drug delivery system†.Pluronic-f127 is also considered as an Thermo Reversible Gelatine of the co-polymer f127 whose generic name is 407 in water makes it an unique candidate for Microencapsulaton application â€Å"Pluronic-f127 is a surfactant molecule with highly beneficial characteristics that makes it a strong candidate for protein drug delivery system. Its interaction with the polypeptides is most likely of minimisation of potential energy by mutual exclusion of hydrophobic residues from the aqueous medium as was predicted by computer probing and verified by fluorescent probing†. 4. Microencapsulation This is a process by which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric material. These micro-capsules have a number of benefits such as converting liquids to solids, separating reactive compounds, providing environmental protection, improved material handling properties. Active materials are then encapsulated in micron-sized capsules of barrier polymers (gelatin, plastic, wax, ). â€Å"The reasons for micro encapsulation are countless. In some cases, the core must be isolated from its surroundings, as in isolating vitamins from the deteriorating effects of oxygen, retarding evaporation of a volatile core, improving the handling properties of a sticky material, or isolating a reactive core from chemical attack. In other cases, the objective is not to isolate the core completely but to control the rate at which it leaves the microcapsule, as in the controlled release of drugs or pesticides†. The problem may be as simple as masking the taste or odour of the core, or as complex as increasing the selectivity of an adsorption or extraction. 4.1 Micro encapsulation techniques: *Physical methods of encapsulation > Rotary disk atomization > Fluid bed coating > Stationary nozzle co extrusion > Centrifugal head co extrusion > Submerged nozzle co extrusion > Spray drying > Pan coating * Chemical methods of encapsulation > Phase separation > Solvent evaporation > Solvent extraction > Interfacial polymerization > Simple and complex coacervation > In-situ polymerization > Liposome technology * Shell materials used for en capsulation > Proteins > Polysaccharides > Starches > waxes > Fats > Natural and synthetic polymers > Resins 4.2 Chemicals used in this experiment: Drug: IBUPROFEN Coating polymer: pvp and pluronic (f77) Phosphate buffer (7.4) Composition of phosphate buffer Ø Potassium chloride Ø Sodium chloride Ø Potassium di hydro ortho phosphate Sodium di hydro ortho phosphate 6. Freeze Drying: Freeze-drying (also known as lyophilisation or cry desiccation) is a dehydration process typically used to preserve a perishable material or make the material more convenient for transport. Freeze-drying works by freezing the material and then reducing the surrounding pressure and adding enough heat to allow the frozen water in the material to sublime directly from the solid phase to gas. There are several stages involved in the freeze drying process 6.1 Freezing stage: â€Å" The freezing process consists of freezing the material. In a lab, this is often done by placing the material in a freeze-drying flask and rotating the flask in a bath, called a shell freezer, which is cooled by mechanical refrigeration, dry ice and methanol, or liquid nitrogen. On a larger-scale, freezing is usually done using a freeze-drying machine. In this step, it is important to cool the material below its eutectic point, the lowest temperature at which the solid and liquid phases of the material can coexist. This ensures that sublimation rather than melting will occur in the following steps. Larger crystals are easier to freeze-dry. To produce larger crystals, the product should be frozen slowly or can be cycled up and down in temperature. This cycling process is called annealing. However, in the case of food, or objects with formerly-living cells, large ice crystals will break the cell walls (discovered byClarence Birdseye)†. Usually, the freezing temperatures ar e between -50  °C and -80  °C. The freezing phase is the most critical in the whole freeze-drying process, because the product can be spoiled if badly done. Amorphous (glassy) materials do not have an eutectic point, but do have a critical point, below which the product must be maintained to prevent melt-back or collapse during primary and secondary drying. 6.2 Primary drying: â€Å" Primary drying can reduce the moisture content of a freeze dried solid to around 0.5%. Further reduction can be effected by secondary drying. During the primary drying, the latent heat of sublimation must be provided and the vapour removed. enough heat is supplied to the material for the water to sublimate In this initial drying phase, about 95% of the water in the material is sublimated. This phase may be slow (can be several days in the industry), because, if too much heat is added, the materials structure could be altered†. 6.3 Secondary drying: The removal of residual moisture at the end o primary drying is performed by raising the temperature of the solid to as high as 50 °C or 60 °C. A high temperature is permissible for many materials because the small amount of moisture remaining is not sufficient to cause spoilage 6.4 Freeze drying advantages: Drying takes place at very low temperatures, so that enzyme action is inhibited and chemical decomposition, particularly hydrolysis, is minimised. The solution is frozen such that the final dry product is a net work of solid occupying the same volume as the original solution. Thus the product is light and porous. The porous form of the product gives ready solubility. There is no concentration of the solution prior to drying. Hence, salts do not concentrate and denature proteins, as occurs with other drying methods. As the process takes place under high vacuum there is little contact with air, and oxidation is minimized. 6.5 Freeze drying disadvantages: The porosity, ready solubility and complete dryness yield a very hygroscopic product. Unless products are dried in their final container and sealed in situ, packaging requires special conditions. The process is very slow and uses complicated plant, which is very expensive. It is not a general method of drying, therefore, but is limited to certain types of valuable products which, because of their heat sensitivity, cannot be dried by any other means. 7 Apparatus used for the experiment : 7.1 Uv_visible spectroscopy: â€Å" A diagram of the components of a typical spectrometer is shown in the following diagram. The functioning of this instrument is relatively straightforward. A beam of light from a visible and/or UV light source (colored red) is separated into its component wavelengths by a prism or diffraction grating. Each monochromatic (single wavelength) beam in turn is split into two equal intensity beams by a half-mirrored device†. One beam, the sample beam (colored magenta), passes through a small transparent container (cuvette) containing a solution of the compound being studied in a transparent solvent. The other beam, the reference (colored blue), passes through an identical cuvette containing only the solvent. The intensities of these light beams are then measured by electronic detectors and compared. The intensity of the reference beam, which should have suffered little or no light absorption, is defined as I0. The intensity ofthe sample beam is defined as I. Over a short perio d of time, the spectrometer automatically scans all the component wavelengths in the manner described. The ultraviolet (UV) region scanned is normally from 200 to 400 nm, and the visible portion is from 400 to 800 nm. [11] Components of UV_ visible spectroscopy 7.2 Instrumentation: Source of light: The best source of light that which is more stable more intense and which gives range of spectrum from 180-360nm.The different sources available are: Hydrogen discharge lamp:It is more stable robust and widely used.It gives radiation from 120-350nm.The lamp consist of hydrogen under pressure. Deuterium lamp: It is similar to hydrogen discharge lamp, but filled with deuterium in the place of hydrogen.It offers 3-5 times more intensity than other types.This is most widely used but expensive. Xenon discharge lamp: In this lamp, xenon at 10-30 atmospheric pressure is filled in and has two tungsten electrodes. The intensity is greater than hydrogen discharge lamp. Mercury arc: This contains mercury vapour and offers bands which are sharp.The spectrum is not continuous. Monochromaters: â€Å"Grating monochromaters are used, filters and prism monochromaters are not used because of low resolution.On the other hand gratings provide a band pass of 0.4 to 2nm.Hence they are more widely used incase of expensive spectrophotometers.The mirrors ,gratings are made up of quartz since glass absorbs uv radiation from 200-300nm.Mirrors are front surfaced to prevent absorption of radiation†. Sample Cells: â€Å"The design of sample cells used is similar to that used in colorimetry expect that it is made up of quartz. Quartz cells only must be used in uv spectroscopy since glass cells will absorb uv radiation.The pathlength of the cells are 10mm or 1cm†. Solvents: â€Å"solvent plays an important role in uv spectra, since compound peak could be obscured by solvent peak.Hence the solvent for a sample is selected in such a way that solvent neither absorbs in the region of measurement nor affects the absorption of the sample†. Detectors: Although any one of the detectors used in colorimetry can be used, photomultiplier tubes are mainly used, since the cost of such UV spectrophotometers are high and more accurate measurements are to be made. Single beam and double beam UV spectrophotometers are used. 7.3.Beers law (related to concentration of absorbing species): Beers law states that the intensity of beam of monochromatic light decreases exponentially with increase in the concentration of absorbing species arithmetically. Lamberts law (related to thickness/ path length of absorbing species): Lamberts law states that the rate of decrease of intensity (monochromatic light) with the thickness of the medium is directly proportional to the intensity of incident light. Beer-Lambert Law: The beer lamberts law states that absorbance of a solution is directly proportionally to the concentration of the solution. A = −log_{10}(I/I_0) = epsiloncdot ccdot L, The beer-lambert law is useful for characterizing of the compounds but does not hold as a universal relationship for the concentration and absorption of all species. Applications: It is mainly used in the detection of impurities. It is used in the structure elucidation of organic compounds. And also used in the analysis of organic compounds. Detrmination of molecular weight. Determination of dissociation constant of acids and bases. 7.4 Flow through dissolution apparatus: â€Å"The flow-through cell is a suitable method for dissolution studies of poorly soluble drugs. The dissolution can be influenced by changing parameters in the apparatus and by changing the physical properties of the drug and the medium used. In this study the dissolution of ibuprofen was examined†. Results showed that a smaller particle size gave a higher dissolution rate. With a dose of 50mg a higher percent dissolved was obtained compared to a dose of 100mg. However, a larger mass (mg) was dissolved when the dose of 100mg was used. When using a cell diameter of 12mm instead of a cell diameter of 22.6mm the dissolution rate increased. A larger dissolution rate was also obtained when the flow of the medium was increased. Finally the effect of changing medium was examined. Results showed that by including a surfactant to the medium a drastic increase of the dissolution rate was obtained. The flow-through cell has since the 90s been used as an alternative method for dissolution studies . It has some advantages over previous dissolution methods. It is easier to retain sink condition, i.e. to keep a sufficiently low concentration in the remaining solution. This makes it possible to keep a constant diving force (=concentration difference) the whole time during the release experiment. The concentration should not exceed one third of the saturated. The medium can be changed automatically during the study which is very useful in in vitro in vivo studies . Previous studies have showed the importance of deaeration of the dissolution medium, how the packing of the cell can influence the dissolution and that the results obtained with the flow-through cell are more reproducible than obtained with previous methods as dissolution baths In this study the dissolution of ibuprofen was examined in the flow-through cell. Six parameters were of interest: The packing of the cell The particle size of the drug The dose The volume flow of the medium through the cell The cell diameter The medium Desirable results were good reproducibility, i.e. small standard deviation between tests and cells, and to maintain sink condition during the experiment. Advantages : Laminar flow characteristics over a wide range of solvent flow rates Infinite sink ideal for low solubility drugs Differential rather than cumulative time profile o